Transcriptional Activator, Hypoxia Inducible Factor-1 BCR/ABL Induces Expression of Vascular Endothelial Growth Factor
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word count: 199 Text word count: 4441 Copyright 2002 American Society of Hematology Blood First Edition Paper, prepublished online July 18, 2002; DOI 10.1182/blood-2002-01-0109 only. For personal use at PENN STATE UNIVERSITY on February 22, 2013. bloodjournal.hematologylibrary.org From
منابع مشابه
BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1 , through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin
Recent data suggest that vascular endothelial growth factor (VEGF), a cytokine involved in autocrine growth of tumor cells and tumor angiogenesis, is upregulated and plays a potential role in myelogenous leukemias. In chronic myelogenous leukemia (CML), VEGF is expressed at high levels in the bone marrow and peripheral blood. We show here that the CML-associated oncogene BCR/ABL induces VEGF ge...
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تاریخ انتشار 2002